Combined modality treatment of operable breast cancer using intraoperative radiotherapy

Objective of the study : To review worldwide literature data on efficacy combined modality treatment including intraoperative radiation therapy (IORT) in patients with operable breast cancer (BC ). Material and М ethods . Of 110 publications (2000–2021) available from Scopus, Pubmed, Elibrary other databases, using key “breast cancer”, “local recurrence”, “intraoperative radiotherapy” “radiation technique”, 45 were included Results Radiotherapy is paramount importance organpreserving cancer, as numerous randomised studies have shown that use postoperative radiotherapy dramatically reduces number locoregional recurrences. The IORT an effective method relapse prevention compared to standard adjuvant important trend oncology. Conclusion. combination for should be differentiated based clinical morphological prognostic factors. Different molecular subtypes are characterized by significant differences pathogenesis response therapy. Further effectiveness required identify a group absolute indications IORT.